Opportunistic Mycelial Fungal Infections in Organ Transplant Recipients: Emerging Importance of Non-Aspergillus Mycelial Fungi
Open Access
- 15 July 2003
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 37 (2), 221-229
- https://doi.org/10.1086/375822
Abstract
To determine the spectrum and impact of mycelial fungal infections, particularly those due to non-Aspergillus molds, 53 liver and heart transplant recipients with invasive mycelial infections were prospectively identified in a multicenter study. Invasive mycelial infections were due to Aspergillus species in 69.8% of patients, to non-Aspergillus hyalohyphomycetes in 9.4%, to phaeohyphomycetes in 9.4%, to zygomycetes in 5.7%, and to other causes in 5.7%. Infections due to mycelial fungi other than Aspergillus species were significantly more likely to be associated with disseminated (P = .005) and central nervous system (P = .07) infection than were those due to Aspergillus species. Overall mortality at 90 days was 54.7%. The associated mortality rate was 100% for zygomycosis, 80% for non-Aspergillus hyalohyphomycosis, 54% for aspergillosis, and 20% for phaeohyphomycosis. Thus, non-Aspergillus molds have emerged as significant pathogens in organ transplant recipients. These molds are more likely to be associated with disseminated infections and to be associated with poorer outcomes than is aspergillosis.Keywords
This publication has 40 references indexed in Scilit:
- Prophylaxis of invasive mycoses in solid organ transplantationCurrent Opinion in Infectious Diseases, 2002
- Epidemiology and Outcome of Mould Infections in Hematopoietic Stem Cell Transplant RecipientsClinical Infectious Diseases, 2002
- Invasive Mold Infections in Allogeneic Bone Marrow Transplant RecipientsClinical Infectious Diseases, 2001
- Invasive Fungal Infections in Liver Transplant Recipients Receiving Tacrolimus as the Primary Immunosuppressive AgentClinical Infectious Diseases, 1997
- Risk factors for systemic fungal infections in liver transplant recipientsEuropean Journal of Clinical Microbiology & Infectious Diseases, 1995
- Bacterial and fungal infections after liver transplantation: An analysis of 284 patientsHepatology, 1995
- Clinical Spectrum of Fungal Infections After Orthotopic Liver TransplantationArchives of Surgery, 1991
- Infections after Liver TransplantationMedicine, 1988
- FUNGAL INFECTIONS IN LIVER TRANSPLANT RECIPIENTSTransplantation, 1985
- Fungus Infections After Liver TransplantationAnnals of Surgery, 1977