Improved Dissolution of Indomethacin in Coprecipitates with Phospholipids-I

Abstract

Indomethacin powders were blended with phospholipids to prepare physical mixtures or made into solid dispersions by the solvent method and their comparative dissolution profiles were studied. Indomethacin exhibited significantly improved dissolution rates in phospholipid coprecipitates compared to either the physical mixtures or the pure indomethacin. The coprecipitates of lecithin-indomethacin 1:16 weight ratio had a 6.5 fold greater initial dissolution rate, and the total amount dissolved after 60 minutes was 140% greater compared to indomethacin alone. Increasing the lecithin content to 1:4 resulted in only a modest additional increase in the initial dissolution rate (40%) and the limiting concentration (14%)