Mobilization of Hematopoietic Stem/Progenitor Cells: General Principles and Molecular Mechanisms
- 7 July 2012
- book chapter
- review article
- Published by Springer Science and Business Media LLC in Methods in Molecular Biology
- Vol. 904, 1-14
- https://doi.org/10.1007/978-1-61779-943-3_1
Abstract
Hematopoietic stem/progenitor cell mobilization can be achieved by a variety of bone marrow niche modifications, although efficient mobilization requires simultaneous expansion of the stem/progenitor cell pool and niche modification. Many of the mechanisms involved in G-CSF-induced mobilization have been described. With regard to mobilization of hematopoietic stem/progenitor cells, challenges for the future include the analysis of genetic factors responsible for the great variability in mobilization responses, and the identification of predictors of mobilization efficiency, as well as the development of mobilizing schemes for poor mobilizers. Moreover, improved regimens for enhanced or even preferential mobilization of nonhematopoietic stem/progenitor cell types, and their therapeutic potential for endogenous tissue repair will be questions to be vigorously pursued in the near future.This publication has 99 references indexed in Scilit:
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