Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study
- 1 January 1978
- journal article
- Published by Springer Science and Business Media LLC in Acta Neuropathologica
- Vol. 42 (2), 73-80
- https://doi.org/10.1007/bf00690970
Abstract
Topographic analysis was performed of the distribution of Alzheimer's neurofibrillary tangles and the granulovacuolar degeneration of Simchowicz in the hippocampal cortex of patients with Alzheimer's dementia and mentally normal aged controls. A semiautomated scanning stage microscope was linked potentiometrically to an XY pen recorder in order to plot cytoarchitectonic “scattergrams” from the sequentially screened hippocampal formations. The density of both lesions per cubic mm of pyramidal cortex was quantified by measuring the area of each of six “zones”, using a digitizer and programmable calculator. In elderly normal brains as well as those of Alzheimer's disease, the statistically most representative ranking order of predilection forneurofibrillary tangles (in decreasing severity) was: entorhinal cortex > subiculum > H1 > end-plate > presubiculum > H2. Forgranulovacuolar degeneration the best rank order was: subiculum > H1 > H2 > end-plate > entorhinal cortex > presubiculum. The notable similarities of both such orders of predilection to the well-recognized “selective vulnerability” of certain hippocampal neurones in clinical conditions of hypoxia, ischemia and epilepsy suggest some common, focally accentuated cytotoxic mechanism may underlie all these regional predispositions.Keywords
This publication has 33 references indexed in Scilit:
- Memory Formation: Evidence for a Specific Neurochemical System in the AmygdalaScience, 1977
- NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIAThe Lancet, 1977
- SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASEThe Lancet, 1976
- Progressive dendritic changes in the aging human limbic systemExperimental Neurology, 1976
- NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIESBrain, 1976
- Screening for neurofibrillary tangles and argyrophilic plaques with Congo Red and polarized light.Journal of Clinical Pathology, 1973
- Granulovacuolar degeneration of hippocampal pyramidal cellsThe Journal of Pathology, 1972
- The Limbic Areas in Alzheimer's Disease and in Other Conditions Associated with DementiaPublished by Wiley ,1970
- The distribution of the internal carotid circulation in the brain of the macaque monkey (Macaca mulatta)Journal of Comparative Neurology, 1966
- The arteries of the mammalian cornu ammonisJournal of Comparative Neurology, 1944