Bcl-2 Protein Family Members: Versatile Regulators of Calcium Signaling in Cell Survival and Apoptosis
- 1 March 2008
- journal article
- review article
- Published by Annual Reviews in Annual Review of Physiology
- Vol. 70 (1), 73-91
- https://doi.org/10.1146/annurev.physiol.70.021507.105852
Abstract
Bcl-2 family members are important regulators of cell survival and cell death. Researchers have focused mainly on mitochondria, where both proapoptotic and antiapoptotic family members function to regulate the release of cytochrome c and other mediators of apoptosis. However, as reviewed here, Bcl-2 family members also operate on another front, the endoplasmic reticulum (ER), to both positively and negatively regulate the release of Ca2+. There is abundant evidence that Ca2+signals trigger apoptosis in response to a wide variety of agents and conditions. Conversely, Ca2+signals can also mediate cell survival. Recent findings indicate that Bcl-2 interacts with inositol 1,4,5-trisphosphate (IP3) receptor Ca2+channels on the ER, regulating their opening in response to IP3and thus inhibiting IP3-mediated Ca2+signals that induce apoptosis while enhancing Ca2+signals that support cell survival.Keywords
This publication has 101 references indexed in Scilit:
- Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosisThe Journal of cell biology, 2006
- Mitochondrial calcium signalling and cell death: Approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosisCell Calcium, 2006
- BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell DeathPublished by Elsevier BV ,2005
- Bcl-2 and calcium: controversy beneath the surfaceOncogene, 2004
- Cell DeathCell, 2004
- Calcium signalling: dynamics, homeostasis and remodellingNature Reviews Molecular Cell Biology, 2003
- BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for ApoptosisScience, 2003
- Depletion of Intracellular Ca2+ by Caffeine and Ryanodine Induces Apoptosis of Chinese Hamster Ovary Cells Transfected with Ryanodine ReceptorPublished by Elsevier BV ,2000
- Protection against hydrogen peroxide cytotoxicity in Rat-1 fibroblasts provided by the oncoprotein Bcl-2: maintenance of calcium homoeostasis is secondary to the effect of Bcl-2 on cellular glutathioneBiochemical Journal, 1999
- Bcl-2 Overexpression Abolishes Early Calcium Waving Preceding Apoptosis in NIH-3T3 Murine FibroblastsBiochemical and Biophysical Research Communications, 1994