Update on primary head and neck mucosal melanoma
Top Cited Papers
- 20 September 2014
- journal article
- review article
- Published by Wiley in Head & Neck
- Vol. 38 (1), 147-155
- https://doi.org/10.1002/hed.23872
Abstract
Primary mucosal melanomas (PMMs) of the head and neck are uncommon malignancies that arise mainly in the nasal cavity and paranasal sinuses, followed by the oral cavity. The mainstay of treatment is radical surgical resection followed by adjuvant radiotherapy in selected patients with high‐risk features. Multimodality therapy has not been well studied and is not standardized. Adjuvant radiotherapy seems to improve locoregional control but does not improve overall survival (OS). Elective neck dissection is advocated in patients with oral PMM. Systemic therapy should be considered only for patients with metastatic or unresectable locoregional disease. Despite improvements in the field of surgery, radiotherapy, and systemic therapy, patients with PMM still face a very unfavorable prognosis (5‐year disease‐free survival [DFS] Head Neck 38: 147–155, 2016Keywords
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