Special regulatory T‐cell review: regulation of immune responses – examining the role of T cells
- 11 December 2007
- journal article
- review article
- Published by Wiley in Immunology
- Vol. 123 (1), 13-16
- https://doi.org/10.1111/j.1365-2567.2007.02775.x
Abstract
The history of regulatory T cells goes back to the realisation that T cells could provide 'help' for antibody responses: the obverse of this is their ability to hold them in check. This brief personal overview follows the initial designation of T cells as 'suppressor' and the various hypotheses, some now disproved, put forward for their mechanism of action. We now cautiously label them T regulatory cells, but realise they do not control not all immune regulation. They probably operate through several mechanisms, and some of these are discussed.Keywords
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