FACTOR XIII (FIBRIN STABILISING FACTOR) IN HENOCH‐SCHÖNLEIN'S PURPURA
- 1 May 1977
- journal article
- research article
- Published by Wiley in Acta Paediatrica
- Vol. 66 (3), 273-277
- https://doi.org/10.1111/j.1651-2227.1977.tb07893.x
Abstract
In 13 of 17 consecutive children with Henoch-Schoenlein''s purpura the factor XIII determined with the dansyl cadaverine method was decreased during the acute phase. The decrease was assumed to be due to a specific degradation by proteolytic enzymes liberated from inflammatory cells, with defective local hemostasis as a result. Treatment with factor XIII combined with an antifibrinolytic drug controlled life-threatening gastrointestinal bleeding in 1 of the patients. Such treatment might offer a new possibility of controlling severe hemorrhages in Henoch-Schoenlein''s purpura.Keywords
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