Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver

Abstract

• Epidemiological evidence connects obesity, diabetes, and NAFLD to osteoporosis. • A complex network of interactions exists among adipose tissue, the liver, and the bone, which reciprocally modulate the bioactivity of each other. • The main mediators of such crosstalk include signals from the bone (including osteopontin, osteocalcin, and osteoprotegerin), signals from the liver (fetuin-A), and signals from adipose tissue (leptin, TNF-α, and adiponectin). • Dysregulation of this network promotes the development of diabetes, obesity, NAFLD, and osteoporosis.