Carcinosarcoma with a large cell neuroendocrine epithelial component: first report of an unusual biphasic tumour of the urinary bladder
Open Access
- 1 March 2004
- journal article
- case report
- Published by BMJ in Journal of Clinical Pathology
- Vol. 57 (3), 318-320
- https://doi.org/10.1136/jcp.2003.013474
Abstract
This article describes the first reported case of carcinosarcoma of the urinary bladder with a large cell neuroendocrine epithelial component. A 61 year old man presented with gross haematuria and underwent resection of a biphasic bladder tumour. The malignant epithelial component showed large cell neuroendocrine differentiation with immunohistochemical reactivity for neurone specific enolase, synaptophysin, and chromogranin. The malignant mesenchymal component did not show specific differentiation by histological or immunohistochemical examination. The differential diagnosis of biphasic tumours in the urinary bladder is discussed, along with a review of the literature.Keywords
This publication has 9 references indexed in Scilit:
- Primary large cell neuroendocrine carcinoma of the urinary bladder.Archives of Pathology & Laboratory Medicine, 2002
- Immunohistomorphologic and molecular cytogenetic analysis of a carcinosarcoma of the urinary bladderVirchows Archiv, 2002
- Carcinosarcoma of the urinary bladder--an aggressive tumor with diverse histogenesis. A clinicopathologic study of 4 cases and review of the literature.Published by Wiley ,2000
- Genetic alterations in urinary bladder carcinosarcoma: evidence of a common clonal origin.European Urology, 2000
- Carcinosarcoma of the urinary bladder: A distinct variant characterized by small cell undifferentiated carcinoma with neuroendocrine featuresVirchows Archiv, 1992
- Unusual forms of carcinoma of the urinary bladderHuman Pathology, 1991
- Neuroendocrine Tumors of the Lung With Proposed Criteria for Large-Cell Neuroendocrine CarcinomaThe American Journal of Surgical Pathology, 1991
- Small Cell Undifferentiated Carcinoma of the Urinary BladderThe American Journal of Surgical Pathology, 1987
- Carcinosarcoma of the urinary bladderCancer, 1987