Cullin-3 and the endocytic system
Open Access
- 1 July 2012
- journal article
- Published by Informa UK Limited in Cellular Logistics
- Vol. 2 (3), 166-168
- https://doi.org/10.4161/cl.20372
Abstract
Cullin-RING-ligases (CRLs) comprise the largest class of multisubunit E3 ubiquitin ligases, which regulate a broad range of cellular processes. Cullin3 (Cul3) recently emerged as an important regulator of intracellular trafficking, in particular secretion and endosome maturation. Here we summarize and discuss possible functions and substrates of Cul3 in the endocytic system.Keywords
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