FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma
- 29 September 2005
- journal article
- research article
- Published by Springer Science and Business Media LLC in Leukemia
- Vol. 19 (12), 2247-2253
- https://doi.org/10.1038/sj.leu.2403965
Abstract
FOXP3 is a forkhead transcription factor family member, implicated in T-cell regulation, activation and differentiation. FOXP3 has been shown to be a master control gene for the development and function of CD4+/CD25+ regulatory T-cells (Treg). In this study, FOXP3 protein expression has been analysed using a new anti-FOXP3 monoclonal antibody in 172 paraffin-embedded lymphoma samples. FOXP3 expression in tumour cells was confined to adult T-cell leukaemia/lymphoma (ATLL) cases (17/25, 68%), with some variability in the intensity of the staining and the proportion of positive cells. No other lymphoma types studied exhibited FOXP3 expression in the malignant population. The selective expression of FOXP3 by tumour cells in ATLL makes this antibody a potentially useful diagnostic tool.Keywords
This publication has 22 references indexed in Scilit:
- Regulation of immunity by self-reactive T cellsNature, 2005
- Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell levelEuropean Journal of Immunology, 2005
- A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3Nature Immunology, 2005
- FOXP3 acts as a rheostat of the immune responseImmunological Reviews, 2005
- Foxp3: a critical regulator of the development and function of regulatory T cellsMicrobes and Infection, 2004
- An essential role for Scurfin in CD4+CD25+ T regulatory cellsNature Immunology, 2003
- Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsNature Immunology, 2003
- Control of Regulatory T Cell Development by the Transcription Factor Foxp3Science, 2003
- IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomenaCurrent Opinion in Pediatrics, 2001
- The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Nature Genetics, 2001