A common variant on chromosome 11q13 is associated with atopic dermatitis
- 30 April 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 41 (5), 596-601
- https://doi.org/10.1038/ng.347
Abstract
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P-combined = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.This publication has 29 references indexed in Scilit:
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseNature Genetics, 2008
- Filaggrin mutations, atopic eczema, hay fever, and asthma in childrenJournal of Allergy and Clinical Immunology, 2008
- Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international studyClinical and Experimental Allergy, 2007
- A genome-wide association study of global gene expressionNature Genetics, 2007
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- Principal components analysis corrects for stratification in genome-wide association studiesNature Genetics, 2006
- Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitisNature Genetics, 2006
- Control of Effector CD8 + T Cell Function by the Transcription Factor EomesoderminScience, 2003
- A general and accurate approach for computing the statistical power of the transmission disequilibrium test for complex disease genesGenetic Epidemiology, 2001
- Atopic dermatitis: A genetic-epidemiologic study in a population-based twin sampleJournal of the American Academy of Dermatology, 1993