Evidence based medicine: a movement in crisis?
Top Cited Papers
Open Access
- 13 June 2014
- Vol. 348 (jun13 4), g3725
- https://doi.org/10.1136/bmj.g3725
Abstract
Trisha Greenhalgh and colleagues argue that, although evidence based medicine has had many benefits, it has also had some negative unintended consequences. They offer a preliminary agenda for the movement’s renaissance, refocusing on providing useable evidence that can be combined with context and professional expertise so that individual patients get optimal treatment It is more than 20 years since the evidence based medicine working group announced a “new paradigm” for teaching and practising clinical medicine.1 Tradition, anecdote, and theoretical reasoning from basic sciences would be replaced by evidence from high quality randomised controlled trials and observational studies, in combination with clinical expertise and the needs and wishes of patients. Evidence based medicine quickly became an energetic intellectual community committed to making clinical practice more scientific and empirically grounded and thereby achieving safer, more consistent, and more cost effective care.2 Achievements included establishing the Cochrane Collaboration to collate and summarise evidence from clinical trials;3 setting methodological and publication standards for primary and secondary research;4 building national and international infrastructures for developing and updating clinical practice guidelines;5 developing resources and courses for teaching critical appraisal;6 and building the knowledge base for implementation and knowledge translation.7 From the outset, critics were concerned that the emphasis on experimental evidence could devalue basic sciences and the tacit knowledge that accumulates with clinical experience; they also questioned whether findings from average results in clinical studies could inform decisions about real patients, who seldom fit the textbook description of disease and differ from those included in research trials.8 But others argued that evidence based medicine, if practised knowledgably and compassionately, could accommodate basic scientific principles, the subtleties of clinical judgment, and the patient’s clinical and personal idiosyncrasies.1 Two decades of enthusiasm and funding have produced numerous successes for …Keywords
This publication has 50 references indexed in Scilit:
- Computer templates in chronic disease management: ethnographic case study in general practiceBMJ Open, 2012
- General health checks in adults for reducing morbidity and mortality from diseaseEmergencias, 2012
- "This does my head in". Ethnographic study of self-management by people with diabetesBMC Health Services Research, 2012
- Measures of Multimorbidity and Morbidity Burden for Use in Primary Care and Community Settings: A Systematic Review and GuideAnnals of Family Medicine, 2012
- The Cochrane Collaboration's tool for assessing risk of bias in randomised trialsBMJ, 2011
- Expediting systematic reviews: methods and implications of rapid reviewsImplementation Science, 2010
- Effect of Directly Observed Therapy for Highly Active Antiretroviral Therapy on Virologic, Immunologic, and Adherence Outcomes: A Meta-Analysis and Systematic ReviewJAIDS Journal of Acquired Immune Deficiency Syndromes, 2010
- Transparent and accurate reporting increases reliability, utility, and impact of your research: reporting guidelines and the EQUATOR NetworkBMC Medicine, 2010
- Effect of financial incentives on inequalities in the delivery of primary clinical care in England: analysis of clinical activity indicators for the quality and outcomes frameworkThe Lancet, 2008
- Selective Publication of Antidepressant Trials and Its Influence on Apparent EfficacyThe New England Journal of Medicine, 2008