Role of the Immune system in chronic pain
Top Cited Papers
- 1 July 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Neuroscience
- Vol. 6 (7), 521-532
- https://doi.org/10.1038/nrn1700
Abstract
During the past two decades, an important focus of pain research has been the study of chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity - spontaneous pain and hyperalgesia - that is associated with these states. For some time it has been recognized that inflammatory mediators released from immune cells can contribute to these persistent pain states. However, it has only recently become clear that immune cell products might have a crucial role not just in inflammatory pain, but also in neuropathic pain caused by damage to peripheral nerves or to the CNS.This publication has 147 references indexed in Scilit:
- Infectious causes of multiple sclerosisThe Lancet Neurology, 2005
- T lymphocytes play a role in neuropathic pain following peripheral nerve injury in ratsNeuroscience, 2004
- N-Formylated humanin activates both formyl peptide receptor-like 1 and 2Biochemical and Biophysical Research Communications, 2004
- Mechanosensation and painJournal of Neurobiology, 2004
- Endothelins contribute towards nociception induced by antigen in ovalbumin‐sensitised miceBritish Journal of Pharmacology, 2004
- Proteinase-activated receptors in the nervous systemNature Reviews Neuroscience, 2003
- Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathyBrain Research, 2001
- Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1British Journal of Pharmacology, 1999
- Responses of macrophages in rat dorsal root ganglia following peripheral nerve injuryJournal of Neurocytology, 1993
- Neutrophil migration induced by inflammatory stimuli is reduced by macrophage depletionInflammation Research, 1988