EFFECT OF CORTICOTROPHIN AND CORTISONE ON THE INCORPORATION OF 3H-THYMIDINE INTO THE DEOXYRIBONUCLEIC ACIDS (DNA) OF THE REGENERATING LIVER IN THE WHITE RAT

Abstract

Both cortisone and ACTH inhibit the incorporation of ³H-thymidine into the DNA of parenchymatous cells in the regenerating rat liver. In addition, the mitotic activity of hepatocytes is markedly impaired. It is assumed that the suppression of mitoses in the regenerating rat liver, caused by cortisone or ACTH, is due to a direct or indirect interference with DNA synthesis.