Morbidity and Mortality in Small for Gestational Age Infants at 22 to 29 Weeks’ Gestation
- 31 January 2018
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 141 (2), e20172533
- https://doi.org/10.1542/peds.2017-2533
Abstract
OBJECTIVES: To identify the relative risks of mortality and morbidities for small for gestational age (SGA) infants in comparison with non-SGA infants born at 22 to 29 weeks’ gestation. METHODS: Data were collected (2006–2014) on 156 587 infants from 852 US centers participating in the Vermont Oxford Network. We defined SGA as sex-specific birth weight RESULTS: Compared with non-SGA infants, the risk of patent ductus arteriosus decreased for SGA infants in early GA and then increased in later GA. SGA infants were also at increased risks of mortality, respiratory distress syndrome, necrotizing enterocolitis, late-onset sepsis, severe retinopathy of prematurity, and chronic lung disease. These risks of adverse outcomes, however, were not homogeneous across the GA range. Early-onset sepsis was not different between the 2 groups for the majority of GAs, although severe intraventricular hemorrhage was decreased among SGA infants for only gestational week 24 through week 25. CONCLUSIONS: SGA was associated with additional risks to mortality and morbidities, but the risks differed across the GA range.This publication has 33 references indexed in Scilit:
- Impact of Fetal Growth Restriction on Mortality and Morbidity in a Very Preterm Birth CohortThe Journal of Pediatrics, 2010
- Neonatal mortality and morbidity in extremely preterm small for gestational age infants: a population based studyArchives of Disease in Childhood: Fetal & Neonatal, 2009
- Can Birth Weight Standards Based on Healthy Populations Improve the Identification of Small-for-Gestational-Age Newborns at Risk of Adverse Neonatal Outcomes?PEDIATRICS, 2009
- Extreme Preterm BirthObstetrics & Gynecology, 2008
- Outcomes of preterm children according to type of delivery onset: a nationwide population‐based studyPaediatric and Perinatal Epidemiology, 2007
- Intrauterine growth restriction increases morbidity and mortality among premature neonatesAmerican Journal of Obstetrics and Gynecology, 2004
- Fetal sex and indicated very preterm birth: results of the EPIPAGE studyAmerican Journal of Obstetrics and Gynecology, 2004
- Excess mortality and morbidity among small-for-gestational-age premature infants: a population-based studyThe Journal of Pediatrics, 2003
- The premature small-for-gestational-age infant during the first year of life: Comparison by birth weight and gestational ageThe Journal of Pediatrics, 1988
- Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants with birth weights less than 1,500 gmThe Journal of Pediatrics, 1978