Switch from cytology‐based to human papillomavirus test‐based cervical screening: Implications for colposcopy
Open Access
- 23 May 2011
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 130 (8), 1879-1887
- https://doi.org/10.1002/ijc.26194
Abstract
Human papillomavirus (HPV) testing is more sensitive than cytology; some cervical cancer prevention programs will switch from cytology to carcinogenic HPV test‐based screening. The objective of our study is to evaluate the clinical implications of a switch to HPV test‐based screening on performance and workload of colposcopy. Women in the population‐based, 7‐year Guanacaste cohort study were screened at enrollment using cytology. We also took another specimen for HPV DNA testing and collected magnified cervical photographic images (cervigrams). A final case diagnosis (≥cervical intraepithelial neoplasia [CIN] grade 3, CIN2, versus specificity trade‐off of the colposcopic impressions would be similar to programs using cytology (≥ atypical squamous cells of unknown significance [ASCUS]) for referral. The major concern with switching from cytology to more sensitive HPV screening is management of the many HPV‐positive women, including those with still nonvisible ≥CIN2 lesions. Our data support the need for a nonvisual diagnostic method to guide management and treatment of HPV‐positive women.This publication has 26 references indexed in Scilit:
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