Distinguishing Characteristics of the Interferon Responses of Primary and Continuous Mouse Cell Cultures

Abstract

Cultures of primary mouse kidney cells and those of L cells produced interferon in response to Newcastle disease virus and polyinosinic-polycytidylic acid. The interferon produced by L cells was made between 8 and 18 hr post-inoculation irrespective of the inducer. The interferon produced by mouse kidney cell cultures in response to Newcastle disease virus was made between 8 and 18 hr while that produced in response to polyinosinic-polycytidylic acid was made between 2 and 12 hr.