Study of nitrazepam interaction with alcohol: an ultrasonic and physiochemical investigation
- 1 December 2021
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 99 (12), 942-949
- https://doi.org/10.1139/cjc-2021-0042
Abstract
The intermolecular interaction between the constituent components of liquid mixtures can be revealed by ultrasonic analysis. In the present study, interaction of nitrazepam with methyl alcohol has been studied and presented using ultrasonic tools. The investigation involves calculation of ultrasonic velocity (υ), density (ρ), viscosity (η), and the associated derived parameters. The specific acoustic impedance (Z), isentropic compressibility (β), relaxation time (τ), intermolecular free length (Lf), and solvation number (Sn) are calculated to reveal the interaction information. The solvent–solvent and solute–solvent interaction between nitrazepam and alcohol molecules is considered. To see the impact of nitrazepam with alcohol in an ordinary day to day scenario, the investigation was carried out under normal temperature (303–313 K) and pressure conditions. The results indicate increased molecule association of nitrazepam in the presence of alcohol. This study suggests the presence of a synergistic depressants effect when nitrazepam is used with alcohol.Keywords
This publication has 28 references indexed in Scilit:
- Synergistic effect of two combinations of antituberculous drugs against Mycobacterium tuberculosisTuberculosis, 2012
- Studies on intermolecular interaction on binary mixtures of methyl orange–water system: Excess molar functions of ultrasonic parameters at different concentrations and at different temperaturesUltrasonics Sonochemistry, 2011
- Thermodynamic and acoustic properties for binary and ternary mixtures of cyclic ethers with industrially important solvents at 308.15 KJournal of Molecular Liquids, 2010
- Calculation of isentropic compressibility and sound velocity in two-phase fluidsFluid Phase Equilibria, 2010
- Estimation of acoustic nonlinearity parameter and molecular characteristics of ternary liquid mixtures at different temperaturesCanadian Journal of Physics, 2010
- Drugs and alcohol: Treating and preventing abuse, addiction and their medical consequencesPharmacology & Therapeutics, 2005
- Interactions of 6-aminopurine (adenine) in water and aqueous urea solutionsCanadian Journal of Chemistry, 2000
- A comparison of the effects of chlormezanone and nitrazepam on sleep.British Journal of Clinical Pharmacology, 1982
- Evaluation of Jacobson's constant and intermolecular free-length as a function of pressure and temperature for cryogenic liquidsUltrasonics, 1979
- 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one (nitrazepam)Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1977