Exploring the role of stem cells in cutaneous wound healing
Open Access
- 19 October 2009
- journal article
- review article
- Published by Wiley in Experimental Dermatology
- Vol. 18 (11), 921-933
- https://doi.org/10.1111/j.1600-0625.2009.00942.x
Abstract
The skin offers a perfect model system for studying the wound healing cascade, which involves a finely tuned interplay between several cell types, pathways and processes. The dysregulation of these factors may lead to wound healing disorders resulting in chronic wounds, as well as abnormal scars such as hypertrophic and keloid scars. As the contribution of stem cells towards tissue regeneration and wound healing is increasingly appreciated, a rising number of stem cell therapies for cutaneous wounds are currently under development, encouraged by emerging preliminary findings in both animal models and human studies. However, we still lack an in‐depth understanding of the underlying mechanisms through which stem cells contribute to cutaneous wound healing. The aim of this review is, therefore, to present a critical synthesis of our current understanding of the role of stem cells in normal cutaneous wound healing. In addition to summarizing wound healing principles and related key molecular and cellular players, we discuss the potential participation of different cutaneous stem cell populations in wound healing, and list corresponding stem cells markers. In summary, this review delineates current strategies, future applications, and limitations of stem cell‐based or stem cell‐targeted therapy in the management of acute and chronic skin wounds.Keywords
This publication has 106 references indexed in Scilit:
- A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cellsExperimental Cell Research, 2008
- Hair Follicle Stem Cells Are Specified and Function in Early Skin MorphogenesisCell Stem Cell, 2008
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem CellsCell, 2008
- Regulation of scar formation by vascular endothelial growth factorLaboratory Investigation, 2008
- Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissueBiochemical and Biophysical Research Communications, 2008
- Inner ear hair cells produced in vitro by a mesenchymal-to-epithelial transitionProceedings of the National Academy of Sciences of the United States of America, 2007
- Autologous Bone Marrow–Derived Cultured Mesenchymal Stem Cells Delivered in a Fibrin Spray Accelerate Healing in Murine and Human Cutaneous WoundsTissue Engineering, 2007
- DNA repair is limiting for haematopoietic stem cells during ageingNature, 2007
- Isolation of a mesenchymal cell population from murine dermis that contains progenitors of multiple cell lineagesThe FASEB Journal, 2007
- Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stromaProceedings of the National Academy of Sciences of the United States of America, 2003