Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study
- 4 May 2012
- journal article
- research article
- Published by Cambridge University Press (CUP) in CNS Spectrums
- Vol. 17 (2), 87-93
- https://doi.org/10.1017/s1092852912000491
Abstract
Objective: To evaluate the clinical features of obsessive-compulsive disorder (OCD) patients with comorbid tic disorders (TD) in a large, multicenter, clinical sample.Method: A cross-sectional study was conducted that included 813 consecutive OCD outpatients from the Brazilian OCD Research Consortium and used several instruments of assessment, including the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, the Yale Global Tic Severity Scale (YGTSS), the USP Sensory Phenomena Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders.Results: The sample mean current age was 34.9 years old (SE 0.54), and the mean age at obsessive-compulsive symptoms (OCS) onset was 12.8 years old (SE 0.27). Sensory phenomena were reported by 585 individuals (72% of the sample). The general lifetime prevalence of TD was 29.0% (n= 236), with 8.9% (n= 72) presenting Tourette syndrome, 17.3% (n= 141) chronic motor tic disorder, and 2.8% (n= 23) chronic vocal tic disorder. The mean tic severity score, according to the YGTSS, was 27.2 (SE 1.4) in the OCD + TD group. Compared to OCD patients without comorbid TD, those with TD (OCD + TD group,n= 236) were more likely to be males (49.2% vs. 38.5%, p < .005) and to present sensory phenomena and comorbidity with anxiety disorders in general: separation anxiety disorder, social phobia, specific phobia, generalized anxiety disorder, post-traumatic stress disorder, attention-deficit hyperactivity disorder, impulse control disorders in general, and skin picking. Also, the “aggressive,” “sexual/religious,” and “hoarding” symptom dimensions were more severe in the OCD + TD group.Conclusion: Tic-related OCD may constitute a particular subgroup of the disorder with specific phenotypical characteristics, but its neurobiological underpinnings remain to be fully disentangled.Keywords
This publication has 40 references indexed in Scilit:
- Towards a post-traumatic subtype of obsessive–compulsive disorderJournal of Anxiety Disorders, 2012
- The relationship between impulse-control disorders and obsessive–compulsive disorder: A current understanding and future research directionsPsychiatry Research, 2009
- O Instituto Nacional de Ciência e Tecnologia de Psiquiatria do Desenvolvimento para a Infância e Adolescência: um novo paradigma para a Psiquiatria Brasileira tendo como foco as nossas crianças e o seu futuroRevista Brasileira de Psiquiatria, 2009
- Obsessive-Compulsive Disorder and Posttraumatic Stress DisorderPsychopathology, 2007
- Obsessive-Compulsive and Spectrum Disorders in Children and AdolescentsPsychiatric Clinics of North America, 2006
- The Dimensional Yale–Brown Obsessive–Compulsive Scale (DY-BOCS): an instrument for assessing obsessive–compulsive symptom dimensionsMolecular Psychiatry, 2006
- Obsessive-compulsive disorder phenotypes: implications for genetic studiesMolecular Psychiatry, 2004
- Adults With Early-Onset Obsessive-Compulsive DisorderAmerican Journal of Psychiatry, 2001
- The role of traumatic experiences in the genesis of obsessive–compulsive disorderBehaviour Research and Therapy, 1999
- The Efficacy of Fluvoxamine in Obsessive-Compulsive DisorderJournal of Clinical Psychopharmacology, 1993