Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress
Open Access
- 16 May 2017
- journal article
- review article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2017, 1-15
- https://doi.org/10.1155/2017/3034245
Abstract
Cocaine abuse has long been known to cause morbidity and mortality due to its cardiovascular toxic effects. The pathogenesis of the cardiovascular toxicity of cocaine use has been largely reviewed, and the most recent data indicate a fundamental role of oxidative stress in cocaine-induced cardiovascular toxicity, indicating that mitochondrial dysfunction is involved in the mechanisms of oxidative stress. The comprehension of the mechanisms involving mitochondrial dysfunction could help in selecting the most appropriate mitochondria injury biological marker, such as superoxide dismutase-2 activity and glutathionylated hemoglobin. The potential use of modulators of oxidative stress (mitoubiquinone, the short-chain quinone idebenone, and allopurinol) in the treatment of cocaine cardiotoxic effects is also suggested to promote further investigations on these potential mitochondria-targeted antioxidant strategies.Keywords
This publication has 131 references indexed in Scilit:
- Regulation of ATP production by mitochondrial Ca2+Cell Calcium, 2012
- Oxidative Stress Biomarkers in Some Rat Brain Structures and Peripheral Organs Underwent CocaineNeurotoxicity Research, 2012
- The effects of idebenone on mitochondrial bioenergeticsBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
- Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overloadFree Radical Biology & Medicine, 2011
- Cocaine-Induced Adaptations in Cellular Redox Balance Contributes to Enduring Behavioral PlasticityNeuropsychopharmacology, 2011
- Cocaine Induces Alterations in Mitochondrial Membrane Potential and Dual Cell Cycle Arrest in Rat C6 Astroglioma CellsNeurochemical Research, 2009
- What is the real physiological NO concentration in vivo?Nitric Oxide, 2009
- Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosisOncogene, 2008
- Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathyFree Radical Biology & Medicine, 2006
- Calcium signalling: dynamics, homeostasis and remodellingNature Reviews Molecular Cell Biology, 2003