De novo mutations in the 5' regulatory region of the Norrie disease gene in retinopathy of prematurity
Open Access
- 1 December 2001
- journal article
- letter
- Published by BMJ in Journal of Medical Genetics
- Vol. 38 (12), 46e-46
- https://doi.org/10.1136/jmg.38.12.e46
Abstract
Editor—Retinopathy of prematurity (ROP) is the commonest cause of potentially preventable blindness in infants.1 2 In developed countries this may reflect the increasing survival of ever more premature babies.3 In emerging countries this may reflect the recent provision of neonatal care.4 5 There is, however, evidence that a genetic component may be involved in the development of severe ROP. For example, the incidence of severe ROP is higher in white infants than in Afro-Caribbean infants in both the United Kingdom6 and the United States.7 There is also great variation in the incidence of severe ROP in different developed countries. In Israel, the incidence of threshold ROP (stage 3 plus or worse) in infants weighing >1000 g is 26%, but none progressed to severe visual loss.8 A similar study in Denmark, however, reported that of 170 infants weighing <1500 g, threshold ROP developed in 26.5% and that 40% of these infants went on to stage 5 ROP despite intervention.9 Norrie disease is an X linked recessive disorder, which is characterised by bilateral retinal dysplasia with retinal detachment, resulting in congenital blindness.10 In addition, approximately one third of patients develop sensorineural hearing loss and a variable spectrum of mental retardation.11 The causative gene for Norrie disease is the NDP gene.12 13 Recently, in a cohort of American patients, mutations in exon 3 of the Norrie's disease protein gene ( NDP ) have been associated with advanced ROP.14 We undertook a study to determine whether NDP mutation may be a factor influencing disease severity in a cohort of patients undergoing investigation in the UK. Such an association would contribute to developing a better understanding of ROP pathophysiology and would provide paediatric ophthalmologists with an adjunctive diagnostic test for predicting likely progression of …Keywords
This publication has 28 references indexed in Scilit:
- X-Linked Wiskott–Aldrich Syndrome in a GirlThe New England Journal of Medicine, 1998
- An Animal Model for Norrie Disease (ND): Gene Targeting of the Mouse Nd GeneHuman Molecular Genetics, 1996
- Mutations in the Norrie disease geneHuman Mutation, 1995
- Manifesting heterozygosity in Norrie's disease?British Journal of Ophthalmology, 1993
- A mutation in the Norrie disease gene (NDP) associated with X–linked familial exudative vitreoretinopathyNature Genetics, 1993
- X-inactivation pattern in carriers of X-linked retinitis pigmentosa: A valuable means of prognostic evaluation?Human Genetics, 1993
- Norrie disease is caused by mutations in an extracellular protein resembling C–terminal globular domain of mucinsNature Genetics, 1992
- Isolation and characterization of a candidate gene for Norrie diseaseNature Genetics, 1992
- Isolation of a candidate gene for Norrie disease by positional cloningNature Genetics, 1992
- Retinopathy of prematurity: incidence and treatment.Archives of Disease in Childhood, 1985