Northwestern University Schizophrenia Data and Software Tool (NUSDAST)
Open Access
- 1 January 2013
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Neuroscience
- Vol. 7, 25
- https://doi.org/10.3389/fninf.2013.00025
Abstract
The schizophrenia research community has invested substantial resources on collecting, managing and sharing large neuroimaging datasets. As part of this effort, our group has collected high resolution magnetic resonance (MR) datasets from individuals with schizophrenia, their non-psychotic siblings, healthy controls and their siblings. This effort has resulted in a growing resource, the Northwestern University Schizophrenia Data and Software Tool (NUSDAST), an NIH-funded data sharing project to stimulate new research. This resource resides on XNAT Central, and it contains neuroimaging (MR scans, landmarks and surface maps for deep subcortical structures, and FreeSurfer cortical parcellation and measurement data), cognitive (cognitive domain scores for crystallized intelligence, working memory, episodic memory, and executive function), clinical (demographic, sibling relationship, SAPS and SANS psychopathology), and genetic (20 polymorphisms) data, collected from more than 450 subjects, most with 2-year longitudinal follow-up. A neuroimaging mapping, analysis and visualization software tool, CAWorks, is also part of this resource. Moreover, in making our existing neuroimaging data along with the associated meta-data and computational tools publically accessible, we have established a web-based information retrieval portal that allows the user to efficiently search the collection. This research-ready dataset meaningfully combines neuroimaging data with other relevant information, and it can be used to help facilitate advancing neuroimaging research. It is our hope that this effort will help to overcome some of the commonly recognized technical barriers in advancing neuroimaging research such as lack of local organization and standard descriptions.Keywords
This publication has 59 references indexed in Scilit:
- Thalamic morphology in schizophrenia and schizoaffective disorderJournal of Psychiatric Research, 2011
- Identifying gene regulatory networks in schizophreniaNeuroImage, 2010
- Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensationSchizophrenia Research, 2010
- Dysregulation of working memory and default‐mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC studyHuman Brain Mapping, 2009
- The emerging discipline of Computational Functional AnatomyNeuroImage, 2009
- Progressive Deformation of Deep Brain Nuclei and Hippocampal-Amygdala Formation in SchizophreniaBiological Psychiatry, 2008
- Test–retest and between‐site reliability in a multicenter fMRI studyHuman Brain Mapping, 2008
- Abnormalities of cingulate gyrus neuroanatomy in schizophreniaSchizophrenia Research, 2007
- Validity of large-deformation high dimensional brain mapping of the basal ganglia in adults with Tourette syndromePsychiatry Research: Neuroimaging, 2007
- Structural analysis of the basal ganglia in schizophreniaSchizophrenia Research, 2007