Recent advances in neurotechnologies with broad potential for neuroscience research
- 16 November 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 23 (12), 1522-1536
- https://doi.org/10.1038/s41593-020-00739-8
Abstract
Interest in deciphering the fundamental mechanisms and processes of the human mind represents a central driving force in modern neuroscience research. Activities in support of this goal rely on advanced methodologies and engineering systems that are capable of interrogating and stimulating neural pathways, from single cells in small networks to interconnections that span the entire brain. Recent research establishes the foundations for a broad range of creative neurotechnologies that enable unique modes of operation in this context. This review focuses on those systems with proven utility in animal model studies and with levels of technical maturity that suggest a potential for broad deployment to the neuroscience community in the relatively near future. We include a brief summary of existing and emerging neuroscience techniques, as background for a primary focus on device technologies that address associated opportunities in electrical, optical and microfluidic neural interfaces, some with multimodal capabilities. Examples of the use of these technologies in recent neuroscience studies illustrate their practical value. The vibrancy of the engineering science associated with these platforms, the interdisciplinary nature of this field of research and its relevance to grand challenges in the treatment of neurological disorders motivate continued growth of this area of study.Funding Information
- Querrey Simpson Institute for Bioelectronics
This publication has 146 references indexed in Scilit:
- Biomaterials‐Based Electronics: Polymers and Interfaces for Biology and MedicineAdvanced Healthcare Materials, 2012
- Photoactivatable Neuropeptides for Spatiotemporally Precise Delivery of Opioids in Neural TissueNeuron, 2012
- Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivoNature Neuroscience, 2011
- Chemical and Genetic Engineering of Selective Ion Channel–Ligand InteractionsScience, 2011
- Regional Slow Waves and Spindles in Human SleepNeuron, 2011
- Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled ReceptorsNeuron, 2009
- Genetic Dissection of Neural CircuitsNeuron, 2008
- Processing of tactile information by the hippocampusProceedings of the National Academy of Sciences of the United States of America, 2007
- Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandProceedings of the National Academy of Sciences of the United States of America, 2007
- Distinct Ensemble Codes in Hippocampal Areas CA3 and CA1Science, 2004