Six-month compliance with antidepressant medication in the treatment of major depressive disorder
- 1 January 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in International Clinical Psychopharmacology
- Vol. 23 (1), 36-42
- https://doi.org/10.1097/yic.0b013e3282f1c1d8
Abstract
The investigation of compliance in patients with major depressive disorder (in drop-outs versus completers and in first episode versus recurrent episode patients). A total of 85 outpatients with major depressive disorder were followed for 6 months. Different dimensions of compliance were investigated: drop-outs versus completers and their medication adherence (with electronic monitoring). General linear mixed models were applied to examine the time courses of adherence. Drop-out rates were higher in younger patients and in patients with a lower initial depression severity. The adherence during 6 months of treatment with selective serotonin reuptake inhibitors was above 80 in 70% of the patients. The adherence decreased by 2.5% per month and decreased more than three times more rapidly in drop-outs (from baseline to time of drop-out). A medical visit resulted in a temporary increase in pill intake. General linear mixed model analysis showed that the predicted outcome was worse in drop-outs than in completers and worse in recurrent episode patients than in first episode patients (the former showing a higher adherence). Adherence decreases with time during 6 months of treatment with antidepressants and is influenced by demographic and clinical variables. Completers show a higher adherence than drop-outs. The outcome was worse in recurrent episode patients than first episode patients although they had a higher adherence.Keywords
This publication has 21 references indexed in Scilit:
- Discontinuation of Use and Switching of AntidepressantsJAMA, 2002
- Adherence to treatment regimen in depressed patients treated with amitriptyline or fluoxetineJournal of Affective Disorders, 2001
- Recovery from episodes during the course of affective disorder: a case-register studyActa Psychiatrica Scandinavica, 1999
- Number of episodes and antidepressant response in major depressionInternational Journal of Neuropsychopharmacology, 1999
- Compliance With Medication Regimens for Mental and Physical DisordersPsychiatric Services, 1998
- Compliance in depressed patients treated with fluoxetine or amitriptylineInternational Clinical Psychopharmacology, 1998
- Natural History of Diagnostic Interview Schedule/ DSM-IV Major DepressionArchives of General Psychiatry, 1997
- Compliance during treatment with antidepressantsJournal of Affective Disorders, 1997
- Recovery from depression: risk or reality?Acta Psychiatrica Scandinavica, 1996
- Understanding compliance with the medical regimen: The scope of the problem and a theoretical perspectiveArthritis & Rheumatism, 1989