Primary invasive micropapillary carcinoma of the colon
- 21 October 2005
- journal article
- case report
- Published by Wiley in Histopathology
- Vol. 47 (5), 479-484
- https://doi.org/10.1111/j.1365-2559.2005.02241.x
Abstract
Aims: Invasive micropapillary carcinoma (IMPC) is associated with frequent lymph node metastasis and adverse clinical outcome. IMPC has been reported in breast, urinary bladder, ureter, lung and parotid gland but not in colon. We present the clinicopathological features of three cases of primary IMPC of the colon with a review of the literature. Methods and results: The patients (one man and two women) were 53, 67 and 68 years old, respectively. The size of the tumour ranged from 20 to 100 mm in diameter. Histologically, all cases were composed predominantly of papillary tumour cell clusters with spaces in a background of fine fibrocollagenous stroma. One of the tumours (case 1) was nearly completely composed of IMPC, but the other two were associated with foci of adenocarcinoma and concurrent mucinous carcinoma, respectively. MUC1 was positive in all cases, suggestive of reverse cell orientation which is responsible for its unique histological features. Conclusions: We report three cases of primary IMPC of the colon. Its clinical significance remains undetermined but the presence of this component may represent a poor prognostic factor.Keywords
This publication has 25 references indexed in Scilit:
- Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoproteinLaboratory Investigation, 2004
- Micropapillary variant of urothelial carcinoma of the urinary bladder; a clinicopathological and immunohistochemical studyHistopathology, 2004
- Invasive Micropapillary Carcinoma of the BreastAmerican Journal of Clinical Pathology, 2004
- Invasive Micropapillary Carcinoma of the Breast : Clinicopathologic Study of 62 Cases of a Poorly Recognized Variant With Highly Aggressive BehaviorAmerican Journal of Clinical Pathology, 2004
- Micropapillary clusters in early-stage lung adenocarcinomasCancer, 2004
- Invasive micropapillary carcinoma of the breast metastatic to the urinary bladder and endometrium: diagnostic pitfalls and review of the literature of tumors with micropapillary featuresAnnals of Diagnostic Pathology, 2003
- Micropapillary Component in Lung AdenocarcinomaThe American Journal of Surgical Pathology, 2002
- Clinicopathologic Analysis of Invasive Micropapillary Differentiation in Breast CarcinomaLaboratory Investigation, 2001
- MICROPAPILLARY BLADDER CARCINOMAJournal of Urology, 1999
- Micropapillary Variant of Transitional Cell Carcinoma of the Urinary Bladder Histologic Pattern Resembling Ovarian Papillary Serous CarcinomaThe American Journal of Surgical Pathology, 1994