Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor
- 1 April 1979
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 278 (5707), 835-838
- https://doi.org/10.1038/278835a0
Abstract
An analog of epidermal growth factor (EGF) which is virtually devoid of biological activity retains receptor binding activity but cannot form cell surface clusters or patches. Bivalent anti-EGF antibodies restore both bioactivity and patch formation. The sensitivity of fibroblasts to native EGF can also be enhanced greatly by these antibodies, especially in hormone-resistant cell lines [mouse 3T3 fibroblasts].This publication has 20 references indexed in Scilit:
- Epidermal growth factor: Biological activity requires persistent occupation of high-affinity cell surface receptorsProceedings of the National Academy of Sciences, 1978
- Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.Proceedings of the National Academy of Sciences, 1978
- Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalizationCell, 1978
- Antibodies to Purified Insulin Receptor Have Insulin-Like ActivityScience, 1978
- Effects of Autoantibodies to the Insulin Receptor on Isolated AdipocytesJCI Insight, 1977
- Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.Proceedings of the National Academy of Sciences, 1977
- 125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.The Journal of cell biology, 1976
- Density dependent proliferation of human glia cells stimulated by epidermal growth factorBiochemical and Biophysical Research Communications, 1976
- Initiation of 3T3 fibroblast cell division by epidermal growth factorJournal of Cellular Physiology, 1975
- Membrane ReceptorsAnnual Review of Biochemistry, 1974