Prostate Cancer Susceptibility Loci: Finding the Genes

Abstract

In 2006 alone, nearly 234,460 men in the USA will be diagnosed with prostate cancer (PC). In addition, about 27,000 will die from, rather than with, their disease (1). Although there is considerable variability in disease incidence by age, race, and family history, about 70% of all cases are ≥65 years (yrs) at diagnosis, and the median age at diagnosis in the USA is 68 yrs (2). The disease is more frequent among African American (AA) than Caucasians; Asian men have the lowest reported incidence (3, 4).