Deregulation of cyclin E meets dysfunction in p53: Closing the escape hatch on breast cancer
- 25 September 2006
- journal article
- review article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 209 (3), 686-694
- https://doi.org/10.1002/jcp.20818
Abstract
In this review, we focus on pathways intersecting through p53 and cyclin E, highlighting how oncogenic effects of cyclin E deregulation, especially overexpression of shortened or low molecular weight (LMW) forms of cyclin E protein, are amplified by loss of regulatory control through p53 to promote tumor development. Expression of cyclin E protein promotes progression into S‐phase, an activity opposed by p53‐regulated activation of checkpoint controls or apoptosis. Loss of p53 function is an escape hatch by which tumor cells, initiated by a number of means including cyclin E deregulation, can avoid cell cycle arrest or cell death and progress through further stages of unchecked deregulation and growth. To determine how this escape hatch is opened and, ultimately, how to close it, we must understand the networks of normal signaling and processing in a cell and where they intersect. J. Cell. Physiol. 209: 686–694, 2006.Keywords
This publication has 214 references indexed in Scilit:
- Stress-induced p53 runs a transcription-independent death programBiochemical and Biophysical Research Communications, 2005
- A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in HumansCell, 2004
- Post-translational modification of p53 in tumorigenesisNature Reviews Cancer, 2004
- N-terminal polyubiquitination and degradation of the Arf tumor suppressorGenes & Development, 2004
- TP53 mutations in familial breast cancer: Functional aspectsHuman Mutation, 2003
- Differential Regulation of E2F1, DP1, and the E2F1/DP1 Complex by ARFMolecular and Cellular Biology, 2002
- Preliminary results of an ongoing phase I and pharmacokinetic study of CYC202, a novel oral cyclin-dependent kinases inhibitor, in patients with advanced malignanciesEuropean Journal Of Cancer, 2002
- Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilizationNature, 2002
- Cancer Cell CyclesScience, 1996
- Different expression patterns of cyclins A, D1 and E in human colorectal cancerZeitschrift für Krebsforschung und Klinische Onkologie, 1996