A118G Single Nucleotide Polymorphism of Human μ-Opioid Receptor Gene Influences Pain Perception and Patient-controlled Intravenous Morphine Consumption after Intrathecal Morphine for Postcesarean Analgesia
- 1 September 2008
- journal article
- pain medicine
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesiology
- Vol. 109 (3), 520-526
- https://doi.org/10.1097/aln.0b013e318182af21
Abstract
Background Previous studies have shown that genetic variability at position 118 of the human mu-opioid receptor gene altered patients' response to intravenous morphine. The purpose of this study was to investigate whether this polymorphism contributes to the variability in response to morphine for postcesarean analgesia. Methods After investigators obtained informed consent, 588 healthy women received 0.1 mg intrathecal morphine for postcesarean analgesia. Their blood samples were genotyped for the A118G polymorphism-A118 homozygous (AA), heterozygous (AG), or homozygous for the G allele (GG). Pain scores, the severity of nausea and vomiting, the incidence of pruritus, and the total self-administered intravenous morphine were recorded for the first 24 postoperative hours. Results Two hundred seventy women (46%) were AA, 234 (40%) were AG, and 82 (14%) were GG. The 24-h self-administered intravenous morphine consumption was lowest in the AA group (P = 0.001; mean, 5.9; 95% confidence interval, 5.1-6.8) versus the AG (8.0; 6.9-9.1) and GG groups (9.4; 7.3-11.5). Pain scores were lowest in the AA group and highest in the GG group, with a statistically significant difference detected between AA, AG, and GG (P = 0.049). Total morphine consumption was also influenced by patients' age and paying status. AA group was associated with the highest incidence of nausea (26 of 272 [9.6%]; P = 0.02) versus the other two groups (13 of 234 [5.6%] and 1 of 82 [1.2%] for AG and GG, respectively). Conclusion Genetic variation at position 118 of the mu-opioid receptor is associated with interindividual differences in pain scores, self-administered intravenous morphine, and the incidence of nausea postoperatively.Keywords
This publication has 18 references indexed in Scilit:
- Human Opioid Receptor A118G Polymorphism Affects Intravenous Patient-controlled Analgesia Morphine Consumption after Total Abdominal HysterectomyAnesthesiology, 2006
- One Size Does Not Fit AllAnesthesiology, 2006
- Association of μ‐opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplastyActa Anaesthesiologica Scandinavica, 2006
- Multifactorial Preoperative Predictors for Postcesarean Section Pain and Analgesic RequirementAnesthesiology, 2006
- The Mu-Opioid Receptor Polymorphism A118G Predicts Cortisol Responses to Naloxone and StressNeuropsychopharmacology, 2005
- The 118 A > G polymorphism in the human µ‐opioid receptor gene may increase morphine requirements in patients with pain caused by malignant diseaseActa Anaesthesiologica Scandinavica, 2004
- Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1)American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 2003
- The Mu-Opioid Receptor Gene Polymorphism (A118G) Alters HPA Axis Activation Induced by Opioid Receptor BlockadeNeuropsychopharmacology, 2002
- Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addictionProceedings of the National Academy of Sciences, 1998
- A new look at the statistical model identificationIEEE Transactions on Automatic Control, 1974