Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen
- 1 April 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 302 (5908), 490-495
- https://doi.org/10.1038/302490a0
Abstract
Potential live vaccines against hepatitis B virus have been produced. The coding sequence for hepatitis B virus surface antigen (HBsAg) has been inserted into the vaccinia virus genome under control of vaccinia virus early promoters. Cells infected with these vaccinia virus recombinants synthesize and excrete HBsAg and vaccinated rabbits rapidly produce antibodies to HBsAg.This publication has 31 references indexed in Scilit:
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