Relationship between vertebral bone marrow blood perfusion and common carotid intima‐media thickness in aging adults
Open Access
- 22 October 2004
- journal article
- research article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 20 (5), 811-816
- https://doi.org/10.1002/jmri.20187
Abstract
Purpose To evaluate the relationship between vertebral marrow blood perfusion and common carotid intima-media thickness (IMT) in aging adults. Materials and Methods An age- and sex-matched case control study was conducted. Subjects were contacted and enrolled voluntarily according to a database containing 2258 cases that received carotid ultrasonography examination at our hospital in the previous two years. Forty-three pairs of subjects (56 male, 30 female; aged 44–85 years, average 63 years) underwent dynamic contrast-enhanced magnetic resonance (MR) study of the lumbar spine. The average peak enhancement percentage of the second to fourth lumbar vertebrae was used to represent the vertebral marrow perfusion status for each subject. The common carotid IMT, presence of plaque, peak enhancement percentage, body mass index (BMI), systolic and diastolic blood pressure, serum total cholesterol, high-density lipoprotein (HDL), and triglycerol levels were acquired for statistical analysis. Results The average peak enhancement percentage was significantly lower in thickened IMT group compared to the normal IMT group (73 ± 23 vs. 90 ± 27, P = 0.0023). The carotid IMT inversely correlated with vertebral peak enhancement percentage (r = −0.33, P = 0.0018). The vertebral peak enhancement percentage was significantly lower in subjects with presence of any carotid plaque (P = 0.032). Common carotid IMT was the only significant variable that was negatively associated with vertebral marrow perfusion after adjusting for the effect of sex, age, blood pressure, BMI, total cholesterol, HDL, and triglycerol level in linear regression model (P = 0.008). Conclusion Our data demonstrate the negative association between vertebral marrow blood perfusion and common carotid IMT. These results suggest that common carotid IMT may provide the information of tissue perfusion status of the vertebral bone marrow. J. Magn. Reson. Imaging 2004;20:811–816.Keywords
This publication has 32 references indexed in Scilit:
- Influence of atherosclerosis on age‐related changes in renal size and functionEuropean Journal of Clinical Investigation, 2003
- Relationship of Early Carotid Artery Disease with Lipoprotein (a), Apolipoprotein B, and Fibrinogen in Asymptomatic Essential Hypertensive Patients and Normotensive SubjectsJournal of Investigative Medicine, 2001
- Carotid Plaque and Intima-Media Thickness Assessed by B-Mode Ultrasonography in Subjects Ranging From Young Adults to CentenariansStroke, 2001
- Prevalence of Asymptomatic Carotid Atherosclerotic Lesions Detected by High-Resolution Ultrasonography and Its Relation to Cardiovascular Risk Factors in the General Population of a Japanese CityStroke, 1997
- Relationship Between Carotid Intima-Media Thickness and Symptomatic and Asymptomatic Peripheral Arterial DiseaseStroke, 1997
- Initial experience with dynamic MR imaging in evaluation of normal bone marrow versus malignant bone marrow infiltrations in humansJournal of Magnetic Resonance Imaging, 1997
- Arterial Wall Thickness Is Associated With Prevalent Cardiovascular Disease in Middle-Aged AdultsStroke, 1995
- Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group.Stroke, 1992
- Cardiovascular determinants of carotid artery disease. The Rotterdam Elderly Study.Hypertension, 1992
- Determinants of carotid intima‐media thickness: a population‐based ultrasonography study in Eastern Finnish menJournal of Internal Medicine, 1991