Rosmarinus officinalis L. Essential Oil Inhibits In Vivo and In Vitro Leukocyte Migration
- 31 August 2011
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Medicinal Food
- Vol. 14 (9), 944-949
- https://doi.org/10.1089/jmf.2010.0159
Abstract
Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring and in folk medicine as an antispasmodic, analgesic, antirheumatic, diuretic, and antiepileptic agent. Few studies have shown the anti-inflammatory effects of rosemary essential oil (REO). This study evaluated the effects of REO on leukocyte migration through in vivo leukocyte migration and in vitro chemotaxis assay. REO was analyzed by using gas chromatography-mass spectometry, and the main components identified were camphor (27.59%), 1,8-cineole (15.74%), alpha-pinene (16.58%), and beta-myrcene (10.02%). In rats, administration of REO reduced the number of leukocytes that rolled, adhered, and migrated to the scrotal chamber after carrageenan injection. All doses of REO tested significantly inhibited leukocyte chemotaxis induced by casein. The effects of REO on leukocyte migration highlight an important mechanism of the anti-inflammatory action of rosemary.This publication has 31 references indexed in Scilit:
- Breaching multiple barriers: leukocyte motility through venular walls and the interstitiumNature Reviews Molecular Cell Biology, 2010
- Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum HayataBioresource Technology, 2008
- Anti-Inflammatory and Antinociceptive Effects of Rosmarinus officinalis L. Essential Oil in Experimental Animal ModelsJournal of Medicinal Food, 2008
- Getting to the site of inflammation: the leukocyte adhesion cascade updatedNature Reviews Immunology, 2007
- Antimicrobial and Antioxidant Properties of Rosemary and Sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) Essential OilsJournal of Agricultural and Food Chemistry, 2007
- Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: Inhibition of cytokine production-dependent mechanismEuropean Journal of Pharmacology, 2007
- Determination of active components in rosemary by capillary electrophoresis with electrochemical detectionJournal of Pharmaceutical and Biomedical Analysis, 2005
- Quality, efficacy and safety of complementary medicines: fashions, facts and the future. Part II: Efficacy and safetyBritish Journal of Clinical Pharmacology, 2003
- Diclofenacinhibits endothelial cell adhesion molecule expression induced with lipopolysaccharideLife Sciences, 1996
- Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs.JCI Insight, 1995