Micro- and Nanocantilever Devices and Systems for Biomolecule Detection
- 19 July 2009
- journal article
- review article
- Published by Annual Reviews in Annual Review of Analytical Chemistry
- Vol. 2 (1), 77-98
- https://doi.org/10.1146/annurev-anchem-060908-155232
Abstract
Recent research trends in biosensing have been geared toward developing bioanalytical devices that are label free, small in size, and portable and that can operate in a rapid manner. The performance of these devices has been dramatically improved through the advent of new materials and micro-/nanofabrication technologies. This is especially true for micro-/nanosized cantilever sensors, which undergo a change in mechanical properties upon the specific binding of biomolecules. In this review, we introduce the basic principles of cantilever biosensors in static and dynamic modes. We also summarize a range of approaches to cantilever design, fabrication, and instrumentation according to their applications. More specifically, we describe cantilever-based detections of proteins, DNA molecules, bacteria, and viruses and discuss current challenges related to the targets’ biophysical characteristics.Keywords
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