The mechanism of the inhibition of the mitochondrial pyruvate transportater by α-cyanocinnamate derivatives
- 15 April 1976
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 156 (1), 181-183
- https://doi.org/10.1042/bj1560181
Abstract
Pyruvate transport into rat liver mitochondria is inhibited by a variety of thiol reagents. alpha-Cyanocinnamate and its derivates, potent and reversible inhibitors of pyruvate transport, react reversibly with mercaptoethanol and cysteine to form addition products. It is concluded that these inhibitors react with an essential thiol group on the pyruvate carrier.This publication has 6 references indexed in Scilit:
- The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by α-Cyano-4-hydroxycinnamate and related compoundsBiochemical Journal, 1975
- The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitorsBiochemical Journal, 1975
- The transport of monocarboxylic oxoacids in rat liver mitochondriaFEBS Letters, 1975
- On the Mechanism of Translocation of Pyruvate and Other Monocarboxylic Acids in Rat‐Liver MitochondriaJBIC Journal of Biological Inorganic Chemistry, 1974
- Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by α-cyano-4-hydroxycinnamate (Short Communication)Biochemical Journal, 1974
- The transport of pyruvate in rat liver mitochondriaFEBS Letters, 1971