Neuroimaging Markers of Risk, Disease Expression, and Resilience to Bipolar Disorder

Abstract

Familial predisposition to bipolar disorder is associated with increased risk of affective morbidity in the first-degree relatives of patients. Nevertheless, a substantial proportion of relatives remain free of psychopathology throughout their lifetime. A series of studies reviewed here were designed to test whether resilience in these high-risk individuals is associated with adaptive brain plasticity.