Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes
Open Access
- 1 September 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 339 (1), 111-120
- https://doi.org/10.1007/s00441-009-0857-z
Abstract
The emergence of multicellular animals could only take place once evolution had produced molecular mechanisms for cell adhesion and communication. Today, all metazoans express integrin-type adhesion receptors and receptors for growth factors. Integrins recognize extracellular matrix proteins and respective receptors on other cells and, following ligand binding, can activate the same cellular signaling pathways that are regulated by growth factor receptors. Recent reports have indicated that the two receptor systems also collaborate in many other ways. Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling.This publication has 99 references indexed in Scilit:
- Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied ForcesMolecular Cell, 2008
- Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironmentsThe Journal of cell biology, 2008
- Direct Binding of Integrin αvβ3 to FGF1 Plays a Role in FGF1 SignalingJournal of Biological Chemistry, 2008
- Structure and mechanics of integrin-based cell adhesionCurrent Opinion in Cell Biology, 2007
- αvβ3 and α5β1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migrationThe Journal of cell biology, 2007
- Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrinsThe Journal of cell biology, 2006
- VEGF receptor signalling ? in control of vascular functionNature Reviews Molecular Cell Biology, 2006
- Integrins: Bidirectional, Allosteric Signaling MachinesCell, 2002
- Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrinsNature Medicine, 2002
- Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv IntegrinsCell, 1998