Hepatitis A immunity in Yozgat, Turkey
Open Access
- 1 January 2019
- journal article
- research article
- Published by King Faisal Specialist Hospital and Research Centre in Annals of Saudi Medicine
- Vol. 39 (1), 37-41
- https://doi.org/10.5144/0256-4947.2019.37
Abstract
BACKGROUND: Since routine immunization could change the epidemiological profile of hepatitis A virus (HAV) infection in the future, it is important to determine the baseline immunity to HAV across Turkey. OBJECTIVE: The aim of this study was to determine the seroprevalence of hepatitis A among individuals 6 years of age and older in Yozgat, Turkey. DESIGN: Cross-sectional. SETTING: Community in central region of Turkey. PATIENTS AND METHODS: Questionnaires and blood specimens were collected and the presence of hepatitis A IgG antibodies against hepatitis A virus was determined quantitatively by ELISA. MAIN OUTCOME MEASURES: The rates of hepatitis A immunity by age group. SAMPLE SIZE: 1862. RESULTS: Immunity to hepatitis A was 79.1% (n=1473). The mean (SD) age was 17.1 (14.7) years in the nonimmune group and 37.8 (19.5) years in the immune group (P<.001), and immunity increased with age. No significant difference in immunity rate was detected between genders in children and adults. The seropositivity rate for subjects ages 6-19 years was lower than in subjects aged 20-96 years (52.2% versus 93.9%; P<.001). CONCLUSION: A catch-up vaccination program is needed for persons aged 6-19 years in Yozgat. LIMITATIONS: Single region data which can not be generalized. For this reason, a multi-centered study that can reflect the whole country is recommended.Keywords
Funding Information
- the Bozok University Scientific Research Project Units (6602a-TF/16-54)
This publication has 8 references indexed in Scilit:
- Hepatitis a virus epidemiology in turkey as universal childhood vaccination begins: seroprevalence and endemicity by regionThe Turkish Journal of Pediatrics, 2016
- The changing pattern of hepatitis A in Lebanese adultsInternational Journal of Infectious Diseases, 2015
- Seroprevalence of Hepatitis A among Different Age Groups in Sakarya and Review of The LiteratureViral Hepatitis Journal, 2014
- Rize İlinde Erişkin Yaş Gruplarında Hepatit A SeroprevalansıViral Hepatitis Journal, 2013
- WHO position paper on hepatitis A vaccines: June 2012—RecommendationsVaccine, 2013
- WHO position paper on hepatitis A vaccines – June 2012.2012
- Seroprevalence and Risk Factors of Hepatitis A Virus Infection in Iran: a Population Based Study2010
- Differences in hepatitis A seroprevalence among geographical regions in Turkey: a need for regional vaccination recommendationsJournal of Viral Hepatitis, 2008