Building and Burying Fear Memories in the Brain
Open Access
- 1 February 2005
- journal article
- review article
- Published by SAGE Publications in The Neuroscientist
- Vol. 11 (1), 89-99
- https://doi.org/10.1177/1073858404269232
Abstract
The world is a dangerous place. Whether this danger takes the form of an automobile careening toward you or a verbal threat from a stranger, your brain is highly adapted to perceive such threats, organize appropriate defensive behaviors, and record the circumstances surrounding the experience. Indeed, memories of fearful events serve a critical biological function by allowing humans and other animals to anticipate future dangers. But these memories can also feed pathological fear, yielding crippling clinical conditions such as panic disorder. In this review, the author will examine how the brain builds fear memories and how these memories come to be suppressed when they no longer predict danger. The review will focus on the fundamental role for synapses in the amygdala in acquiring fear memories and the function of neural circuits interconnecting the amygdala, hippocampus, and prefrontal cortex in modulating the expression of such memories once learned. The discovery of the neural architecture for fear memory highlights the powerful interplay between animal and human research and the promise for understanding the neurobiological mechanisms of other complex cognitive phenomena.Keywords
This publication has 100 references indexed in Scilit:
- THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCESAnnual Review of Neuroscience, 2004
- New Vistas on Amygdala Networks in Conditioned FearJournal of Neurophysiology, 2004
- NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdalaEuropean Journal of Neuroscience, 2004
- Amygdalar NMDA Receptors Control the Expression of Associative Reflex Facilitation and Three Other Conditional Responses.Behavioral Neuroscience, 2004
- Auditory-Evoked Spike Firing in the Lateral Amygdala and Pavlovian Fear ConditioningNeuron, 2003
- The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1Neuron, 2003
- Neurons in medial prefrontal cortex signal memory for fear extinctionNature, 2002
- Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdalaNature, 1990
- The neural basis of basic associative learning of discrete behavioral responsesTrends in Neurosciences, 1988
- Innate and conditioned reactions to threat in rats with amygdaloid lesions.Journal of Comparative and Physiological Psychology, 1972