Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes
- 28 May 2003
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 17 (14), 1517-1527
- https://doi.org/10.1002/rcm.1030
Abstract
Electrospray ionization mass spectrometry (ESI‐MS) coupled to liquid chromatography (LC) has been applied to investigate cisplatin and its hydrated complexes. Three hydrolysis products were identified following incubation of cisplatin in aqueous solution: monohydrated species, dihydrated species and the hydroxo‐bridged dimer, each of which exhibited characteristic mass spectrometric behavior. The technique was employed to investigate the time‐ and pH‐dependent hydrolysis of cisplatin in aqueous solution. The results have demonstrated that LC/ESI‐MS is a powerful technique for the analysis of Pt(II) complexes and for monitoring their hydrolysis reactions. Copyright © 2003 Crown in the right of Canada. Published by John Wiley & Sons, Ltd.This publication has 44 references indexed in Scilit:
- Liquid chromatography-mass spectrometry for the detection of platinum antineoplastic complexesJournal of Pharmaceutical and Biomedical Analysis, 1996
- High-performance liquid chromatographic determination of cis-dichlorodiammineplatinum(II) in plasma ultrafiltrateJournal of Pharmaceutical and Biomedical Analysis, 1995
- New Cisplatin Analogues in DevelopmentDrugs, 1993
- Platinum antitumour agents: A review of (bio)analysisInternational Journal of Clinical Pharmacy, 1992
- Sensitive Determination of Cisplatin in Body Fluids with HPLC and On-Line Reductive Electrochemical DetectionJournal of Liquid Chromatography, 1990
- Structural characterization of cisplatin analogues by fast atom bombardment (FAB) and laser microprobe mass spectrometry (LAMMA)Journal of Pharmaceutical and Biomedical Analysis, 1989
- Bioanalysis of cisplatin analogues — a selective reviewJournal of Pharmaceutical and Biomedical Analysis, 1988
- Fourier transform mass spectrometry of cisplatin and analoguesJournal of Pharmaceutical and Biomedical Analysis, 1985
- Fast atom bombardment, field desorption, and desorption chemical ionization mass spectrometry of cis-dichloroplatinum amino acid and dipeptide complexesInternational Journal of Mass Spectrometry and Ion Processes, 1984
- cis-Platinum(II) amine complexes: Some structure-activity relationships for immunosuppressive, nephrotoxic and gastrointestinal (side) effects in ratsChemico-Biological Interactions, 1980