Comparison of plasma and saliva concentrations of the active monohydroxy metabolite of oxcarbazepine in patients at steady state
- 1 October 1995
- journal article
- clinical trial
- Published by Wiley in Biopharmaceutics & Drug Disposition
- Vol. 16 (7), 603-614
- https://doi.org/10.1002/bdd.2510160708
Abstract
A study was performed in ten patients, stabilized with oxcarbazepine monotherapy (450–750 mg bid) for two weeks minimum, to investigate the possibility of using saliva to monitor the oxcarbazepine therapy. Thirteen paired blood and saliva samples were taken over 24h. The saliva samples were obtained after stimulation. The analysis performed on the data suggests a dose dependence for the relationship between plasma and saliva concentrations of the main active metabolite, 10, 11‐dihydro‐10‐hydroxycarbamazepine (MHD), and the importance of the type of stimulation for the saliva's production. Therefore it would be preferable to use plasma concentrations to monitor oxcarbazepine therapy, if necessary.Keywords
This publication has 10 references indexed in Scilit:
- Clinical Pharmacology and Pharmacokinetics of OxcarbazepineEpilepsia, 1994
- Comparative Pharmacokinetics of the Newer Antiepileptic DrugsClinical Pharmacokinetics, 1993
- Analytical Methods Validation: Bioavailability, Bioequivalence, and Pharmacokinetic StudiesJournal of Pharmaceutical Sciences, 1992
- Lack of enzyme induction with oxcarbazepine (600 mg daily) in healthy subjects.British Journal of Clinical Pharmacology, 1991
- Use of saliva for monitoring oxcarbazepine therapy in epileptic patientsEuropean Journal of Clinical Pharmacology, 1986
- A comparison of plasma and saliva levels of carbamazepine and phenytoin as monotherapyIrish Journal of Medical Science, 1984
- The Place of Saliva in Antiepileptic Drug MonitoringTherapeutic Drug Monitoring, 1984
- Determination of oxcarbazepine in human plasma by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1983
- Pharmacokinetics of 10-OH-carbazepine, the main metabolite of the antiepileptic oxcarbazepine, from serum and saliva concentrationsActa Neurologica Scandinavica, 1983
- Saliva carbamazepine levels in children before and during multiple dosing.British Journal of Clinical Pharmacology, 1982