Selective and Potent Proteomimetic Inhibitors of Intracellular Protein–Protein Interactions
Open Access
- 4 February 2015
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 54 (10), 2960-2965
- https://doi.org/10.1002/anie.201410810
Abstract
Inhibition of protein–protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α-Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed “proteomimetics”, which can be assembled in a modular manner to reproduce the vectoral presentation of key side chains found on a helical motif from one partner within the PPI. In this work, it is demonstrated that by using a library of N-alkylated aromatic oligoamide helix mimetics, potent helix mimetics which reproduce their biophysical binding selectivity in a cellular context can be identified.This publication has 62 references indexed in Scilit:
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