Major Expansion of γδ T Lymphocytes following Cytomegalovirus Infection in Kidney Allograft Recipients
Open Access
- 1 January 1999
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 179 (1), 1-8
- https://doi.org/10.1086/314568
Abstract
In normal persons, circulating γδ T cells comprise a minor cell subset (0.5%–6% of total lymphocytes). γδ T cells were studied in the context of therapeutic immunosuppression in transplanted patients. Flow cytometry detected an expansion of γδ T cells in 31 of 205 renal allograft recipients and in 2 of 41 uremic patients but in none of 45 healthy subjects. Univariate statistical analysis identified cytomegalovirus (CMV) infection (P < .001), second graft (P < .001), and antithymocyte globulin treatment (P = .01) as three variables associated with high levels (⩾6%) of circulating γδ T cells in allograft recipients. Multivariate analysis further indicated that CMV infection was the only independent parameter associated with > 6% γδ T cells. γδ T cell expansion directly followed CMV infection and was never observed in persons who did not develop CMV infection. Thus γδ T cells may represent a first-line defense mechanism against CMV infection in a person whose αβ T cell response has been weakened by immunosuppression.Keywords
This publication has 1 reference indexed in Scilit:
- 1994 Revised Guidelines for the Performance of CD4+ T-Cell Determinations in Persons with Human Immunodeficiency Virus (HIV) InfectionPublished by American Psychological Association (APA) ,1994