Pharmacology of Intraperitoneal Chemotherapy
- 1 January 1983
- journal article
- review article
- Published by Informa UK Limited in Cancer Investigation
- Vol. 1 (5), 395-407
- https://doi.org/10.3109/07357908309048508
Abstract
In this review of the pharmacology and clinical application of intraperitoneal drug administration, we have tried to acquaint the reader with the current state of the art. At this juncture it is important to outline briefly some of the major remaining questions. First, as we have discussed, the analysis of tumor penetration is at present poorly formulated and needs more detailed analysis. Second, the current catheter arrangements are adequate but certainly not ideal. Third, there is need for Phase I and pharmacologic data on additional drugs to provide greater flexibility in terms of combination chemotherapy. Finally, and most importantly, there is a need for a series of careful randomized clinical trials to be done which will assess the clinical value of this form of treatment in the situations listed in Table 3.Keywords
This publication has 19 references indexed in Scilit:
- Concentration-Dependent Disappearance of Fluorouracil from Peritoneal Fluid in the Rat: Experimental Observations and Distributed ModelingJournal of Pharmaceutical Sciences, 1982
- Distribution and tissue dose of intraperitoneally administered radioactive chromic phosphate (32P) in New Zealand white rabbits.Radiology, 1980
- Advanced Ovarian AdenocarcinomaNew England Journal of Medicine, 1978
- The effect of volume on the distribution of substances instilled into the peritoneal cavityGynecologic Oncology, 1978
- Transport of Model Compounds across the Peritoneal Membrane in the RatPharmacology, 1978
- Adjuvant liver perfusion in colorectal cancer: initial results of a clinical trial.BMJ, 1977
- Lymphatic drainage of the peritoneal cavity and its significance in ovarian cancerAmerican Journal of Obstetrics and Gynecology, 1974
- Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target TissuesJCI Insight, 1973
- Carcinoma of the Ovary: A clinicopathological study of 86 autopsied cases with special reference to mode of spreadActa Obstetricia et Gynecologica Scandinavica, 1966
- The physiologic disposition of 5‐fluorouracil and 5‐fluoro‐2′‐deoxyuridine in manCancer Cell, 1964