Oligomerization of G-protein-coupled transmitter receptors
Top Cited Papers
- 1 April 2001
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Neuroscience
- Vol. 2 (4), 274-286
- https://doi.org/10.1038/35067575
Abstract
Examples of G-protein-coupled receptors that can be biochemically detected in homo- or heteromeric complexes are emerging at an accelerated rate. Biophysical approaches have confirmed the existence of several such complexes in living cells and there is strong evidence to support the idea that dimerization is important in different aspects of receptor biogenesis and function. While the existence of G-protein-coupled-receptor homodimers raises fundamental questions about the molecular mechanisms involved in transmitter recognition and signal transduction, the formation of heterodimers raises fascinating combinatorial possibilities that could underlie an unexpected level of pharmacological diversity, and contribute to cross-talk regulation between transmission systems. Because G-protein-coupled receptors are major pharmacological targets, the existence of dimers could have important implications for the development and screening of new drugs. Here, we review the evidence supporting the existence of G-protein-coupled-receptor dimerization and discuss its functional importance.Keywords
This publication has 88 references indexed in Scilit:
- The Extracellular Calcium-sensing Receptor Dimerizes through Multiple Types of Intermolecular InteractionsJournal of Biological Chemistry, 2001
- Cys-140 Is Critical for Metabotropic Glutamate Receptor-1 DimerizationPublished by Elsevier BV ,2000
- Molecular tinkering of G protein-coupled receptors: an evolutionary successThe EMBO Journal, 1999
- Intracellular Retention of Recombinant GABABReceptorsPublished by Elsevier BV ,1998
- A Human Orphan Calcitonin Receptor-like StructureBiochemical and Biophysical Research Communications, 1995
- Solubilization and Characterization of D2-Dopamine Receptors in an Estrone-Induced, Prolactin-Secreting Rat Pituitary AdenomaJournal of Neurochemistry, 1986
- Gonadotropin releasing hormone activation is mediated by dimerization of occupied receptorsBiochemical and Biophysical Research Communications, 1985
- Molecular size of the human platelet alpha2-adrenergic receptor as determined by radiation inactivationBiochemical and Biophysical Research Communications, 1983
- The size of the mammalian lung β2-adrenergic receptor as determined by target size analysis and immunoaffinity chromatographyBiochemical and Biophysical Research Communications, 1982
- β-Adrenergic receptors: Evidence for negative cooperativityBiochemical and Biophysical Research Communications, 1975