Ubiquitin signalling in the NF-κB pathway
- 1 August 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 7 (8), 758-765
- https://doi.org/10.1038/ncb0805-758
Abstract
The transcription factor NF-κB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-κB pathway: degradation of IκB (inhibitor of NF-κB), processing of NF-κB precursors, and activation of the IκB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.This publication has 83 references indexed in Scilit:
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