Increased circulatory RAS activity can be inhibited by statins in patients with hypercholesterolemia
Open Access
- 28 March 2013
- journal article
- Published by SAGE Publications in Journal of the Renin-Angiotensin-Aldosterone System
- Vol. 16 (1), 126-130
- https://doi.org/10.1177/1470320313483349
Abstract
Objective: The objective of this paper is to investigate a profile on circulatory renin−angiotensin system (RAS) activity in hypercholesterolemic (HC) patients treated with statins. Methods: Eighteen primary HC patients and 18 sex- and age-matched healthy adults were included in this study as controls. Total cholesterol (TC), triglyceride (TG), LDL-C, blood glucose, angiotensin-converting enzyme (ACE) activity, and angiotensin II (Ang II) levels were measured before and four and eight weeks after beginning statin treatment in the HC group. Similar measurements were taken in the control group at baseline. Results: At baseline, TC, TG and LDL-C levels, as well as ACE activity and Ang II concentrations, were significantly higher in the HC group than in the control group. Based on the baseline data collection of 36 participants, there were significant positive correlations between ACE activity and TC (r = 0.54) or LDL-C (r = 0.51), and between Ang II level and TC (r = 0.34) or LDL-C (r = 0.27). TC, LDL-C, Ang II (35.46±14.49 vs 71.10±20.47 pg/ml, p < 0.05) levels and ACE activity (108.9±51.9 vs 180.1±71.3 U/L, p < 0.05) were decreased in HC patients eight weeks after starting statin treatment. In HC patients, RAS activity correlated positively with TC and LDL-C levels before and after treatment. Conclusions: In HC patients, lowering serum cholesterol with statins is associated with decreased circulatory RAS activity.Keywords
This publication has 21 references indexed in Scilit:
- Effects of Statins on Cardiorenal SyndromeInternational Journal of Vascular Medicine, 2012
- The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndromeAmerican Journal of Physiology-Heart and Circulatory Physiology, 2012
- Combination therapy for treatment or prevention of atherosclerosis: Focus on the lipid-RAAS interactionAtherosclerosis, 2010
- Augmentation Of The Renin–Angiotensin System By Hyper Cholesterolemia Promotes Vascular DiseasesFuture Lipidology, 2008
- Hypercholesterolaemia exacerbates ventricular remodelling after myocardial infarction in the rat: role of angiotensin II type 1 receptorsBritish Journal of Pharmacology, 2008
- Comparison of Cardiovascular Events in Patients With Angiographically Documented Coronary Narrowing With Combined Renin-Angiotensin System Inhibitor Plus Statin Versus Renin-Angiotensin System Inhibitor Alone Versus Statin Alone (from the Japanese Coronary Artery Disease Study)The American Journal of Cardiology, 2007
- Low-density Lipoproteins Induce the Renin-Angiotensin System and their Receptors in Human Endothelial CellsHormone and Metabolic Research, 2007
- Simvastatin Normalizes Autonomic Neural Control in Experimental Heart FailureCirculation, 2003
- Review: Renin-angiotensin system antagonism and lipid-lowering therapy in cardiovascular risk managementJournal of the Renin-Angiotensin-Aldosterone System, 2002
- Statins as antioxidant therapy for preventing cardiac myocyte hypertrophyJCI Insight, 2001