Evaluating counseling outcome on adherence to prophylaxis and follow-up after sexual HIV-risk exposure: a randomized controlled trial
- 6 December 2010
- journal article
- research article
- Published by Informa UK Limited in AIDS Care
- Vol. 22 (12), 1509-1516
- https://doi.org/10.1080/09540121.2010.484457
Abstract
Objective. Post-exposure prophylaxis (PEP) is recommended for the management of sexual HIV-risk exposure. However, a high percentage of exposed patients discontinue both their 28-day prophylaxis course before 15 days and HIV testing follow-up before M3. The objective of this study is to assess the efficacy of a counseling intervention in enhancing both adherence to PEP and HIV testing follow-up. Methods. Between 1 June 2004 and 31 December 2005, 54 patients exposed to sexual HIV-risk exposure were included in a multicenter, prospective, controlled, randomized trial, comparing a group receiving a counseling intervention in addition to traditional medical management (intervention group (IG), n=28) vs. a control group (CG, n=26). Patients in the IG received interactive counseling interventions focused on adherence to PEP and to HIV testing follow-up, led by specially trained nurses. The main outcome measures were proportion of patients achieving 100% adherence to PEP as evaluated on D15 by a self-completed patient questionnaire and on HIV testing on D45 and M3. Results. Groups were well balanced at baseline for age, sex, and circumstances of exposure. The proportion of 100% adherent patients to PEP was significantly higher in the IG compared to the CG (54% vs. 23%, p=0.036). Patients in the IG were more likely to complete the HIV testing follow-up at D45 (86% vs. 54%, p=0.023) and M3 (68% vs. 38%, p=0.056). Conclusions. This study suggests the effectiveness of a counseling program to enhance adherence to both PEP and HIV testing follow-up after sexual exposure.Keywords
This publication has 24 references indexed in Scilit:
- Diagnostic Value of Different Adherence Measures Using Electronic Monitoring and Virologic Failure as Reference StandardsAIDS Patient Care and STDs, 2008
- Determinants of High-Risk Sexual Behavior during Post-Exposure Prophylaxis to Prevent HIV InfectionAIDS and Behavior, 2007
- Post-exposure HIV prophylaxis following sexual exposure: a retrospective audit against recent draft BASHH guidanceSexually Transmitted Infections, 2006
- UK Guideline for the use of post-exposure prophylaxis for HIV following sexual exposureInternational Journal of STD & AIDS, 2006
- Impact of a Patient Education Program on Adherence to HIV MedicationJAIDS Journal of Acquired Immune Deficiency Syndromes, 2003
- The Dynamic of Adherence to Highly Active Antiretroviral Therapy: Results From the French National APROCO CohortJAIDS Journal of Acquired Immune Deficiency Syndromes, 2001
- Feasibility of Postexposure Prophylaxis (PEP) against Human Immunodeficiency Virus Infection after Sexual or Injection Drug Use Exposure: The San Francisco PEP StudyThe Journal of Infectious Diseases, 2001
- Self-Reported Symptoms After Initiation of a Protease Inhibitor in HIV-Infected Patients and Their Impact on Adherence to HAARTHIV Research & Clinical Practice, 2001
- Factors Affecting Adherence to Antiretroviral TherapyClinical Infectious Diseases, 2000
- A Case–Control Study of HIV Seroconversion in Health Care Workers after Percutaneous ExposureNew England Journal of Medicine, 1997